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Updated: Sep 9, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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DCAF7は,クロコファジー誘発フェロプトーシスを抑制することによって,肝細胞がんの進行を促進するためにUSP2を勧誘する

Honglv Jiang1, Xiaohui Wang1, Zhenhua Zhu2

  • 1Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, The Fourth Affiliated Hospital of Soochow University, Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, Suzhou Key Laboratory of Drug Research for Prevention and Treatment of Hyperlipidemic Diseases, Soochow University, Suzhou, Jiangsu, China.

Cell death & disease
|August 28, 2025
PubMed
まとめ

DDB1およびCUL4関連因子7 (DCAF7) とUSP2は肝がんにおけるフェロプトーシスを抑制する. これらのタンパク質を標的にすると 特定の種類の細胞死 (クロコファジー) を促進することで 腫瘍の成長を阻害します

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