自閉症のための補完的・代替的・統合的医療:総括的な見直しとオンラインプラットフォーム
Corentin J Gosling1,2,3, Laure Boisseleau4, Marco Solmi5,6,7,8,9
1DysCo Laboratory, Paris Nanterre University, Nanterre, France. corentin.gosling@parisnanterre.fr.
Nature human behaviour
|August 28, 2025
まとめ
補完的・代替的・統合的医療 (CAIM) は自閉症において一般的であるが,その有効性に関する証拠は不足している. この総括的なレビューでは,CAIMが自閉症の個人に利益をもたらすという高品質の証拠は見つかりませんでした.
科学分野:
- 神経発達障害
- 統合医療
- 証拠 に 基づく 実践
背景:
- 補完的,代替的,統合的医学 (CAIM) は自閉症スペクトル障害 (ASD) の個人が広く使用しており,90%までが生涯使用していると報告しています.
- 自閉症の症状に対するCAIM介入の有効性を支持する科学的証拠は依然として不確実であり,厳格な評価が必要です.
- 自閉症に対するCAIMの効果と安全性の理解には大きなギャップがある.
研究 の 目的:
- 自閉症におけるCAIM効果の証拠を評価するためのメタ分析の総括的なレビューを行う.
- 自閉症におけるCAIM介入の方法論的質と確実性を評価する.
- 自閉症のためのCAIMの発見を広めるためのアクセシブルなウェブプラットフォームを開発する.
主な方法:
- 2023年12月31日までの5つのデータベースを検索したメタ分析による体系的なレビューの総括レビューが行われました.
- 適格なメタ分析は,一貫した統計的アプローチを用いて再評価され,品質はAMSTAR-2で,証拠確実性はGRADEで評価された.
- 合計53件のメタ分析報告が特定され,自閉症に関する19のCAIMに関する248件のメタ分析が実施された.
主要な成果:
- 自閉症スペクトル障害の主要な症状または関連する症状に対するCAIMの有効性を支持する高品質の証拠は見つかりませんでした.
- いくつかのCAIMは有望な結果を示したが,支持する証拠は一貫して非常に低品質であった.
- 自閉症に対するCAIM介入の安全性が評価されることはめったになく,これは将来の研究の重要な分野を示しています.
結論:
- 現在の証拠は,自閉症の症状の治療にCAIMの使用を支持していません.
- 有望なCAIM介入に対する証拠の質が低いため,慎重に解釈し,さらなる調査が必要である.
- インタラクティブなウェブプラットフォーム (https://ebiact-database.com) が開発され,自閉症に関するエビデンスベースの意思決定を支援しました.
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