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Updated: Sep 9, 2025

Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity
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AIベースの進化と抗原性モデルによるインフルエンザワクチンの株選択

Wenxian Shi1, Jeremy Wohlwend2, Menghua Wu2

  • 1Department of Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA. wxsh@mit.edu.

Nature medicine
|August 28, 2025
PubMed
まとめ

VaxSeerは新しい計算法で ワクチンとウイルスのマッチを予測し インフルエンザワクチンの有効性を高めます このアプローチは,将来のウイルスの優位性と抗原プロフィールを予測することで,現在の方法を改善します.

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Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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