Search research articles

お問い合わせ

JoVEについて

概要リーダーシップブログ JoVEヘルプセンター

著者向け

出版プロセス編集委員会範囲と方針査読よくある質問投稿

図書館員向け

推薦の声購読アクセスリソース図書館諮問委員会よくある質問

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments アーカイブ

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教員リソースセンター教員サイト

プライバシーポリシー

関連する概念動画

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え

Same author

Assessment of Maladaptive Exercise History Among Individuals With Eating Disorders: Validation of a Brief, Self-Report Measure.

European eating disorders review : the journal of the Eating Disorders Association·2026

Same author

Māori Experiences of Eating Disorders: A Scoping Review of How Little We Know.

European eating disorders review : the journal of the Eating Disorders Association·2026

Same author

Maladaptive Exercise in People With a Lifetime History of Eating Disorders: A Multicountry Observational Study.

The International journal of eating disorders·2025

Same author

Functional Consequences Paternal Preconceptual Alcohol Consumption.

Current topics in behavioral neurosciences·2025

Same author

The effect of mixed tobacco monoamine oxidase inhibitors in animal models relevant to tobacco dependence.

Psychopharmacology·2024

Same author

Priorities for data collection through a prospective cohort study on gender-affirming hormone therapy in Aotearoa New Zealand: community and clinical perspectives.

Journal of primary health care·2024

Search research articles

関連する実験動画

Updated: Sep 9, 2025

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

産前と産後のバルプロアート暴露は脳発達に影響する

Michaela A Pettie¹, Linda C M Wilkin-Krug², Bart Ellenbroek³

¹Department of Pathology and Biomedical Science, Ōtākou Whakaihu Waka - University of Otago, Christchurch, New Zealand.

Current topics in behavioral neurosciences

|August 28, 2025

まとめ

バルプロ酸の曝露は,投与量依存の脳変化と行動変化を引き起こすことで,歯類における自閉症スペクトル障害 (ASD) をモデル化しています. これらの動物モデルの人間関連性を改善するためにさらなる研究が必要である.

キーワード:

自閉症スペクトル障害ロコモーター活動神経発達社会的行動テラトジェニシティ超音波による発声バルプロアート

さらに関連する動画

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

関連する実験動画

Last Updated: Sep 9, 2025

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

科学分野:

神経科学
発達生物学
毒理学について

背景:

バルプロ酸 (VPA) は,脳の発達に重大な影響を及ぼす,知られたテロゲンである.
動物モデルは,薬物による神経発達効果を理解し,自閉症スペクトル障害 (ASD) などの人間の障害をモデル化するために不可欠です.

研究の目的:

ネズミのモデルにおけるバルプロ酸の脳発達に対するテロジェニック効果を検証する.
VPA 曝露に関連した用量依存およびタイミングによる神経行動的アウトカムを調査する.
自閉症スペクトル障害の動物モデルとしてのVPAの有用性と限界を評価する.

主な方法:

バルプロ酸にさらされたラットとマウスを用いた研究の体系的レビュー.
行動評価 (社会的相互作用,運動活動) と神経生物学的変化 (海馬,小脳) の分析
異なる投与方法 (口腔投与,腹膜内注射) と歯類の株を考慮する.

主要な成果:

様々なネズミのモデルで社会的相互作用の障害や運動活動の変化を含む行動の変化の一貫した報告
特に海馬と小脳で,VPA暴露に関連した神経の変化が観察されました.
VPA 曝露と神経発達の結果の間の用量依存関係を裏付ける証拠

結論:

ネズミのバルプロ酸曝露は,特定の自閉症スペクトル障害のような行動と神経生物学的な変化を効果的にモデル化します.
VPAが神経発育に及ぼすテロゲン性影響について,投与量とタイミングを把握することが重要です.
価値あるものの,モデル妥当性の課題のために,発見を人間の条件に推論する際には限界があります.