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Updated: Sep 9, 2025

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
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産前と産後のバルプロアート暴露は脳発達に影響する

Michaela A Pettie1, Linda C M Wilkin-Krug2, Bart Ellenbroek3

  • 1Department of Pathology and Biomedical Science, Ōtākou Whakaihu Waka - University of Otago, Christchurch, New Zealand.

Current topics in behavioral neurosciences
|August 28, 2025
PubMed
まとめ

バルプロ酸の曝露は,投与量依存の脳変化と行動変化を引き起こすことで,歯類における自閉症スペクトル障害 (ASD) をモデル化しています. これらの動物モデルの人間関連性を改善するためにさらなる研究が必要である.

キーワード:
自閉症スペクトル障害ロコモーター活動神経発達社会的行動テラトジェニシティ超音波による発声バルプロアート

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Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
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