台湾における微細粒子 (PM2.5) の大気汚染と出生時の性別比率との関連
Shang-Shyue Tsai1, Chih-Cheng Chen2, Chun-Yuh Yang3,4
1Department of Healthcare Administration, I-Shou University, Kaohsiung, Taiwan.
Journal of toxicology and environmental health. Part A
|August 29, 2025
まとめ
微細粒子 (PM2. 5) により高い曝露は,台湾における出生時の性別比率 (SRB) の増加と関連していた. この発見は,男性胎児の脆弱性に関する予想に反して,生殖健康に潜在的な環境影響を示唆しています.
科学分野:
- 環境 健康
- 生殖伝染病学
- 大気汚染に関する研究
背景:
- 出生時の性別比 (SRB) は人口の生殖健康の重要な指標です.
- 世界的なSRBの傾向は下落を示しており,内分泌系を乱す化学物質 (EDC) のような環境毒素と関連している可能性がある.
- 空気汚染とSRBに関する以前の研究は矛盾した結果をもたらした.
研究 の 目的:
- 周囲のPM2.5への長期的曝露とSRBの数との関連を調査する.
- 台湾の66の自治体におけるこの関係を分析する.
主な方法:
- 台湾内務省の年間出生データと環境保護局 (TEPA) のPM2.5データを利用した.
- 計算された平均PM2.5レベルとSRB (2010-2023)
- 線形ロジスティック回帰を用いて,PM2.5 (低,中,高) の三位数におけるSRBの動向を評価した.
主要な成果:
- 高いPM2.5レベルとSRBの増加を関連付ける重要な傾向が観察されました.
- 調整されたオッズ比 (ORs) は,中位と最高位のPM2.5トートリルに対して,それぞれ1.015 (1.006-1.024) と1.018 (1.008-1.029) であった.
- 観察された傾向は,男性胎児の環境的危険に対するより高い感受性と矛盾しています.
結論:
- 長期にわたる環境PM2.5への曝露は,台湾の出生時の性別比率の増加と関連しています.
- この発見は 性別決定や胎児生存に 環境が及ぼす影響の可能性を強調しています
- この予期せぬ関連性とその生殖健康への影響の仕組みを明らかにするためにさらなる研究が必要である.
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