関連する実験動画
Updated: Sep 9, 2025
08:41
Mouse Round Spermatid Injection
Published on: January 26, 2024
918
精子生成の誘導とその予測因子 予後性発症性低子腺症の男性で,高子腺素療法を受けている
Min Chul Cho1, Hohyun Lee2, Soo Woong Kim3
1Department of Urology, Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
The world journal of men's health
|August 29, 2025
まとめ
ゴナドトロピン療法 (GT) は,思春期前におけるヒポゴナドトロピック・ヒポゴナディズム (HH) を有する男性の82%で精子生成を成功させる. 精巣の量が増えると 精子の生成が早まる
科学分野:
- 内分泌学
- 生殖医学
- 男性 不妊症
背景:
- 青春期前のヒポゴナドトロピクヒポゴナディズム (HH) は,不十分なゴナドトロピンの産生によって特徴づけられ,青春期間の発達障害と不妊症につながる.
- これらの個体における精子生成の誘発は,生殖能力の回復と正常な性成熟の達成に不可欠です.
研究 の 目的:
- 妊娠前期発症のHHを誘発するヒト腺ホルモン (hCG) と再結合卵泡刺激ホルモン (rFSH) を用いた性腺ホルモン治療 (GT) の有効性を評価する.
- 生まれながらのHH病因と既得のHH病因の治療結果を比較する.
- 精子生成誘導の成功の予測要因を特定する.
主な方法:
- 青春期前発症のHHを患った65人の男性をGTで分析した.
- 治療には,最初のhCG注射と,その後のrFSHとhCGの併用療法が含まれていました.
- 精子生成は精子分析で少なくとも1つの精子の存在として定義され,結果は丸の体積と精子パラメータに基づいて評価された.
主要な成果:
- 精子生成は平均7. 5ヶ月で患者の82% (41/ 50) で成功しました.
- 治療後の丸の体積は4. 0mLから9. 0mLに増加した.
- 先天性および既得性HH病因における成功率の有意な差は認められず,精子生成の成功と早期の精子生成の唯一の予測要因は精子の量でした.
結論:
- 黄経前発症のHHの男性における精子生成を誘導する非常に効果的な治療法です.
- 精子生成誘導の成功とタイミングを予測する重要な要因です.
- HHの病因に関係なく,GTは,この患者集団における生育回復のための実行可能な選択肢を提供します.
さらに関連する動画
関連する概念動画
01:41Spermatogenesis
103.3K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
103.3K
01:23Infertility in Males
331
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
331
01:26Testosterone: Functions and Regulation
1.0K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
1.0K
01:27Signs of Puberty
606
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
606
01:24Gonadal and Placental Hormones
1.7K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.7K
01:22Hormonal Regulation of the Menstrual Cycle
688
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
688