パーキンソン病患者の潜在的に不適切な薬物使用:韓国国民健康保険請求データ分析
Seon-Min Lee1,2, Jieun Shin3, Do-Young Kwon4
1Department of Neurology, Konyang University College of Medicine, Daejeon, Korea.
Journal of clinical neurology (Seoul, Korea)
|August 29, 2025
まとめ
潜在的に不適切な薬 (PIM) は,韓国人のパーキンソン病 (PD) 患者で2014年から2019年にかけて頻繁に使用されました. PDの症状を悪化させるPIMも一般的であり,よりよいポリファーマ管理戦略の必要性を強調しています.
科学分野:
- ゲロントロジー
- 薬理学について
- 神経科学
背景:
- パーキンソン病 (PD) の治療には多剤療法が一般的です.
- これには適切な薬と不適切な薬 (PIMs) が含まれます.
- 2019年のビール基準は,PIMを特定するためのガイドラインを提供します.
研究 の 目的:
- 韓国人のPD患者に対する PIMの処方傾向を分析する.
- PDの症状を悪化させる可能性のあるPIMを特定する.
- 2019年のビール基準に基づいてPIMの使用を評価する.
主な方法:
- 2014年から2019年までのPD患者 (≥40歳) の遡及観察研究.
- 韓国の健康保険審査と評価サービス (HIRA) の請求データベースを利用した.
- 流行,使用,および特定のPIMとPDを分析した.
主要な成果:
- 257, 142人のPD患者の38. 3%がPIMを使用した.
- アミトリプチリンは最も頻繁なPIMであり,レボスルピリドとハロペリドールは一般的なPIM^PDでした.
- PIMの使用傾向は2018年まで減少し,2019年には増加した.
結論:
- 韓国人のPD患者におけるPIMとPIM^PDの高い流行と使用 (2014年−2019年).
- PDの症状を悪化させる PIMの継続的な使用
- 発見は,PDにおけるより安全なポリ薬局管理のためのガイドラインの開発を支援します.
さらに関連する動画
07:26Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
Published on: September 26, 2019
8.0K
06:25Paw-Print Analysis of Contrast-Enhanced Recordings PrAnCER: A Low-Cost, Open-Access Automated Gait Analysis System for Assessing Motor Deficits
Published on: August 12, 2019
8.6K
関連する概念動画
01:24Parkinson's Disease: Treatment
376
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
376
01:15Parkinson's Disease: Overview
702
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
702
01:12Analysis of Population Pharmacokinetic Data
382
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
382
01:28Drug Therapy
96
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
96
01:19Pharmacovigilance
983
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
983
00:59Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis
124
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
124