関連する実験動画
Updated: Sep 9, 2025

08:06
Identification of Kinesin-1 Cargos Using Fluorescence Microscopy
Published on: February 14, 2016
8.0K
乳がんにおけるキネシンスーパーファミリーの予測的意義: 系統的レビューとメタ解析
Shagufta1,2, Mehreen Aftab1, Sandeep Sisodiya1,3
1Department of Cellular & Molecular Diagnostics, ICMR-National Institute of Cancer Prevention and Research, Noida, India.
The Indian journal of medical research
|August 29, 2025
まとめ
キネシン超家族タンパク質 (KIF) 濃度の上昇は,乳がん患者における生存率の低下と関連しています. このメタアナリシスは,KIFをBCの進行と患者の管理のための潜在的な予後バイオマーカーとして確認しました.
科学分野:
- 腫瘍学
- 分子生物学
- バイオ統計学
背景:
- キネシン超家族タンパク質 (KIF) は,細胞分裂と輸送に不可欠な運動タンパク質です.
- KIFは乳がん (BC) の進行における役割としてますます認識されています.
- BCにおける予後バイオマーカーおよび治療標的としての可能性は調査中です.
研究 の 目的:
- 乳がん患者におけるKIF発現レベルと生存結果との関連を調査する.
- 全生存期 (OS),再発性生存期 (RFS),遠隔転移性生存期 (DMFS) の潜在的な予後バイオマーカーとしてKIFを評価する.
主な方法:
- PRISMAのガイドラインに従って,体系的なレビューとメタ分析が行われました.
- PubMedとScienceDirectのデータベースで行った文献検索 (1996年6月 - 2024年10月)
- RevManソフトウェアを用いた11の適格な研究から抽出した危険比率 (HRs) と95%信頼区間 (CI).
主要な成果:
- KIF発現の上昇は,OSの低下と有意に関連していた (HR=1. 77,P< 0. 001).
- KIF値の上昇は,RFS (HR=1. 40,P< 0. 001) とDMFS (HR=1. 72,P< 0. 001) の低下と相関していた.
- これらの発見は,KIFがBCにおける生存率の低下と転移のリスクの増大に寄与することを示しています.
結論:
- キネシン超群のタンパク質は,乳がんの予後バイオマーカーとして有意な可能性を示しています.
- KIF発現の上昇は,BC患者における不良生存結果のマーカーである.
- これらの洞察は,乳がんの臨床的意思決定と患者管理に役立ちます.
関連する概念動画
Destabilization of Microtubules
2.8K
The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
2.8K
Microtubule Associated Motor Proteins
8.5K
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
8.5K
mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
The Movement of Organelles and Vesicles
4.7K
In eukaryotic cells, cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
4.7K
Microtubule Formation
5.9K
Microtubules are dynamic structures that undergo continuous assembly and disassembly. They originate from specialized multi-protein complexes known as microtubule organizing centers or MTOCs. Within the MTOC, the point of origin of the microtubule is known as the minus end, while the end radiating outward is the plus end. Microtubules serve two primary functions — the organization of spindle complexes to separate sister chromatids during mitotic or meiotic cell division and the formation...
5.9K
Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K

