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Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

Replicative Cell Senescence

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...

Replicative Cell Senescence

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...

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Updated: May 12, 2026

Gentle Isolation of Nuclei from the Brain Tissue of Adult African Turquoise Killifish, a Naturally Short-Lived Model for Aging Research

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単核トランスクリプトミクスに基づくヒト脳細胞型老化時計

Chandramouli Muralidharan^1,2,3, Enikő Zakar-Polyák^4,5,6, Anita Adami¹

¹Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund, 221 84, Sweden.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|August 29, 2025

まとめ

科学者はヒトの脳データを用いて細胞型特異のトランスクリプトミア老化時計を開発しましたこれらの時計は異なる脳細胞の生物学的老化を正確に測定し神経退行性疾患における老化の変化を明らかにします

キーワード:

古い時計生物学的な時計人間の脳の老化単核のシーケンシングトランスクリプトミッククロック

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科学分野:

神経科学
ゲノミクス
老化に関する研究

背景:

老化は神経変性疾患の主な危険因子です
細胞特異的な脳老化を理解することは極めて重要ですが十分に理解されていません

研究の目的:

ヒトの細胞型に特化したトランスクリプトミックの老化時計を開発し,検証する.
細胞の老化パターンを研究する
神経変性疾患における老化経路の変化を調査する

主な方法:

死亡後のヒト前頭皮質 (31人のドナー,18歳から94歳) の単核RNAシーケンシングデータを利用した.
主要な脳細胞型に訓練されたトランスクリプトミックな老化時計を開発した
独立したデータセットで検証されたクロック性能.

主要な成果:

マイクログリアの炎症遺伝子のアップレギュレーションを含む,異なる細胞タイプでの老化に関連した明確なトランスクリプトミックの変化を特定した.
老化時計は年代を正確に予測し生物学的に重要な経路を捉えました
独立したデータセットのクロックの堅実性を証明した.
アルツハイマー病や統合失調症患者の細胞型特異的な加齢を観察した.

結論:

細胞型特異のトランスクリプトーム時計は,人間の脳の生物学的老化を測定するための可能なツールです.
これらの時計は神経退行性疾患の変化した老化経路を特定できます
この発見は,神経疾患における選択的脆弱性の潜在的なメカニズムを強調しています.