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Updated: May 5, 2026

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

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新しいチアジアゾールベースのVEGFR-2阻害剤の発見:設計,合成,細胞毒性,およびアポトーシス誘導

Eslam B Elkaeed1, Walid E Elgammal2, Hazem Elkady3

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.

Future medicinal chemistry
|August 29, 2025
PubMed
まとめ

新しいチアジアゾール化合物は,VEGFR-2を標的とした潜在的な癌療法として開発されました. 化合物11aは強力で選択的な阻害を示し,癌細胞死を誘発し,既存の治療法に有望な代替手段を提供しました.

キーワード:
ドッキング試験MDシミュレーションチアジアゾール系VEGFR-2 阻害剤乳がん

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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