健康なライフスタイルと脳卒中との間の血圧の仲介効果:中国・カドリー・バイオバンク研究の結果
Zidong Wang1, Jiaxi Zhou1, Xikang Fan2
1School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Journal of biomedical research
|August 29, 2025
まとめ
健康的なライフスタイルは脳卒中リスクを大幅に低減し,血圧 (BP) はこの保護効果の約40%を媒介する. 脳卒中の予防におけるライフスタイルの介入の有効性を評価する上で, 血圧をコントロールすることが重要です.
科学分野:
- 心血管伝染病学
- 予防 医療
- 公衆衛生
背景:
- 健康的なライフスタイルは 脳卒中のリスクを減らすと認められています
- この関連を媒介する血圧 (BP) の正確な役割については,さらなる定量化が必要である.
研究 の 目的:
- 健康的なライフスタイルと脳卒中発生率との関係におけるシストリック血圧 (SBP) とダイアストリック血圧 (DBP) の媒介効果を定量化する.
主な方法:
- 51,929人の参加者のデータを基に構造式モデリングを行いました.
- 追跡期間中の脳卒中の発生率に対するSBPとDBPの媒介効果の評価
- 追跡期間中に2,811件の脳卒中が確認された.
主要な成果:
- 健康的なライフスタイルは,脳卒中リスクの減少と有意に関連していました.
- 健康的なライフスタイルと脳卒中との関連は,SBPが44. 70%,DBPが37. 81%を媒介した.
- これらの媒介効果は,衰弱したものの,不全性脳卒中では依然として有意であった (SBP: 33. 21%, DBP: 27. 24%).
結論:
- 健康的なライフスタイルに起因する脳卒中リスクの 約5分の2は 血圧によるものです
- 血圧のコントロールは 脳卒中の予防を目的としたライフスタイルの介入の有効性の重要な早期指標として機能します
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