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Updated: Sep 9, 2025

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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早期のリウマチ性関節炎におけるCTLA-4Ig治療反応と溶解性免疫チェックポイント分子PD1および4 - 1BBの関連

Tilia Selldén1, Kristina Lend2, Jon Lampa3

  • 1Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

ACR open rheumatology
|August 29, 2025
PubMed
まとめ

早期の関節リウマチ患者における溶解性プログラム細胞死-1 (sPD1) と溶解性4-1BB (s4-1BB) の高いレベルは,メトトレキサート療法によるアバテセプトに対する良好な反応を予測する. これらのバイオマーカーは,PD1+ T毛細血管ヘルパー細胞と組み合わせて,治療の寛解を予測する可能性があることを示しています.

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