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Updated: Sep 9, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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DNMT3Aの生殖系および体内変異および未定の潜在遺伝子の他のクローン性血液形成は,肺動脈高血圧に寄与する

Ruaa Al-Qazazi1, Isaac M Emon1, François Potus2

  • 1Department of Medicine, Queen's University, Biosciences Complex Room 1520, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6.

European heart journal
|August 29, 2025
PubMed
まとめ

DNMT3AとCHIP遺伝子の生殖系と体内の変異は,肺動脈高血圧 (PAH) のリスクの増加と関連しています. これらの遺伝要因は炎症を促進し,PAHの治療標的として機能する.

キーワード:
DNA (サイトシン5) メチルトランスファーゼ3アルファ (DNMT3A) • 肺動脈高血圧関連PPM1D • ソマティック遺伝子変種結合組織疾患DNAメチル化

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