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Updated: Sep 9, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

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PI3K/ AKT/ HIF-1α経路の異常な活性化により,肝がんにおけるグリコロシスとレンバチニブ耐性が促進される

Jinfeng Wang1, Jianfei Shi1, Lili Mi1

  • 1Department of Gastroenterology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035, P.R. China.

Molecular medicine reports
|August 29, 2025
PubMed
まとめ

肝がんにおけるレンヴァチニブ耐性は,PI3K/ AKT/ HIF- 1α経路と有酸素糖解の増加と関連している. この経路をLY294002で阻害すると,レンバチニブの感受性が回復し,潜在的な治療戦略が提供されます.

キーワード:
LY294002についてグリコリスレンバチニブに対する耐性肝臓がんフォスファディチリンシトール3キナーゼ/タンパク質キナーゼB/低酸素誘導因子-1α経路

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