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Updated: Sep 9, 2025

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
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口腔状細胞癌患者からの血清は,T細胞の調節分化とT細胞枯渇を促進することによって,腫瘍の免疫脱出の生態的ニッチを再構成する

Hongli Chen1, Jiao Chen1, Bomiao Cui1

  • 1State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases and West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Oncology reports
|August 29, 2025
PubMed
まとめ

口腔がん患者の血清は,T細胞の調節とT細胞の疲労を増加させることで,免疫脱出を促進します. これは体の抗腫瘍反応を阻害し 癌のバイオセラピーの戦略に影響します

キーワード:
T細胞の枯渇エコロジカルニッチ癌患者さん規制T細胞血清について

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Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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