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Updated: Sep 9, 2025

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
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チオプリンを含む化学療法による子宮内暴露後の子供における同一の体内PTPN11変異を有する若年性骨髄性白血病の2症例

Marek Ussowicz1, Monika Rosa1, Monika Biedroń2

  • 1Department of Pediatric Bone Marrow Transplantation, Oncology, and Hematology, Wroclaw Medical University, Wroclaw, Poland.

Pediatric blood & cancer
|August 29, 2025
PubMed
まとめ

胎児のチオプリン化学療法への曝露は,若年性骨髄性白血病 (JMML) と関連している可能性があります. 子宮内で被曝した2人の子どもは,同じPTPN11変異を持つJMMLを発症し,このまれな小児がんの潜在的な環境トリガーを示唆しています.

キーワード:
子宮内での被曝青少年の骨髄単細胞性白血病チオプリン

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Teratogenicity01:07

Teratogenicity

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