ステージBの心不全患者のサルコペニアの流行と予後的影響: PAPRIKA- HFコホート研究
Koichiro Matsumura1, Shun Morishita2, Junko Morimoto3
1Department of Cardiology, Kindai University Faculty of Medicine, Osakasayama, Japan.
Journal of the American Geriatrics Society
|August 29, 2025
まとめ
サルコペニア,または筋肉の喪失は,ステージBの心不全 (HF) の高齢患者の長期的な見通しを著しく悪化させる. サルコペニアの早期発見は,この脆弱な集団の予後を改善するために不可欠です.
科学分野:
- 高齢者医療
- 心臓病科
- 臨床栄養について
背景:
- 心不全 (HF) の予後は,特に高齢者では悪い.
- サルコペニアを含む老年症候群は,HF患者でより悪い結果と関連しています.
- ステージBのHFにおけるサルコーペニアの流行と予後効果はよくわかっていません.
研究 の 目的:
- ステージBのHFを患っている高齢者のサルコペニアの罹患率を決定する.
- この集団におけるサルコペニアの長期的な予後効果を調査する.
主な方法:
- PAPRIKA- HF研究には,ステージBのHFを患った65歳以上の外科医312人が参加しました.
- サルコペニアは,サルコペニア2019のアジアワーキンググループの基準を用いて診断された.
- 主なエンドポイントは,全因死亡率,心筋梗塞,または2年以上のHF入院でした.
主要な成果:
- 患者の17. 7% (56/312) がサルコペニアと診断された.
- サルコペニアの患者では,2年後の複合エンドポイント率が著しく高かった (25. 0%対2. 7%,p < 0. 0001).
- サルコペニアは,長期的な予後が悪い独立した予測因子であった (HR: 5. 78, p < 0. 001).
結論:
- サルコペニアは,ステージBのHFを患っている高齢者に一般的です.
- サルコペニアは長期的な予後が著しく悪化する.
- 早期診断と治療は,ステージBのHFにおいて重要です.
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