2000年から2022年のスウェーデンのコホートにおける,HPV型16陽性および他の高リスクHPV型陽性口腔状細胞癌の年齢と腫瘍の呈現は異なっている.
PubMedで要約を見る
まとめ
この要約は機械生成です。ヒトパピローマウイルス陽性口腔状細胞癌 (HPV+OPSCC) の患者は若く,HPV16陽性患者は他の高リスクHPV型よりも若くなります. この年齢の差は,近年ではより顕著です.
科学分野
- 腫瘍学
- ウイルス学
- 流行病学
背景
- ヒトパピローマウイルス陽性口腔状細胞癌 (HPV+ OPSCC) の発生率は上昇しており,HPV16型が過去から優勢である.
- 以前の研究結果によると,HPV+ OPSCC患者は,HPV陰性 (HPV-) 患者よりも年少で,予後が良いという.
- 最近の傾向は,年齢差が減り,他の高リスク型HPV (HR-HPV) が増加していることを示唆しています.
研究 の 目的
- HPV16陽性OPSCCと他のHR- HPV型陽性OPSCCの患者の年齢差を調べる.
- OPSCCにおける異なるHR-HPV型に関連した人口統計学的および臨床的特徴を分析する.
主な方法
- スウェーデン・ストックホルム・ゴットランド地域の1681人のOPSCC患者 (2000年~2022年) の遡及分析.
- 感染をHPV16,その他のHRHPV,低リスクHPV,HPV陰性に分類する.
- HPVサブグループ間の年齢,性別,腫瘍の特徴の統計的比較
主要な成果
- HPV+ OPSCC患者は,HPV- OPSCC患者より (平均66. 5) 明らかに若かった.
- HPV+ OPSCCでは,HPV16陽性患者 (平均61. 1) が他のHR- HPV型陽性患者 (平均64. 5) よりも著しく若かった.
- HPV16陽性OPSCC患者では,腫瘍が小さく,年齢差が顕著であったのは,近年 (2010年−2022年) であった.
結論
- 特に近年では,HPV16陽性と他のHR-HPV型陽性OPSCCの年齢差が顕著である.
- OPSCCにおけるHPV16型以外のHR型の流行が増加しているため,さらなる調査が必要である.
- 発見は,HPVによって引き起こされる口がんにおける流行病学的パターンの進化を強調しています.
関連する概念動画
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

