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Updated: Sep 9, 2025

Assaying the Kinase Activity of LRRK2 in vitro
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Published on: January 18, 2012

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パーキンソン病におけるLRRK2 p.V1447Lの機能的および構造的特徴

Neringa Pratuseviciute1, Pawel Lis1, Sacha Weber2

  • 1Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.

Movement disorders : official journal of the Movement Disorder Society
|August 29, 2025
PubMed
まとめ

新しいLRRK2変種であるp.V1447Lはキナーゼ活性を著しく上昇させ,パーキンソン病 (PD) の病原性である可能性を示唆する. この発見は,PDの病原性におけるLRRK2の役割の理解を広げています.

キーワード:
LRRK2パーキンソン病ラブ10のリン酸化遺伝学外周血液中性粒子は

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