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Updated: Sep 9, 2025

Human Saphenous Vein Endothelial Cell Isolation and Exposure to Controlled Levels of Shear Stress and Stretch
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APEX1-STAT3信号は,力調整された内皮再生を媒介する

Yueqi Liu1, Chuanrong Zhao1, Zhenhui Liang1

  • 1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, National Health Commission Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University, Beijing, 100191, China.

Cellular and molecular life sciences : CMLS
|August 29, 2025
PubMed
まとめ

血管壁の硬さは損傷後に動的に変化し,内皮の再生を促進します. アプリニク/アピリミディンエンドヌクレアゼ1 (APEX1) とシグナルトランスデューサーおよびトランスクリプションアクティベーター3 (STAT3) の相互作用を高め,細胞修復を促します.

キーワード:
内皮機能マトリックス硬さ機械的な力フェーズ分離再内皮化

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