セプシスが骨髄のメゼンキマ幹細胞に及ぼす影響と,血液形成と免疫抑制への影響
Thatiana Correa de Melo1, Suely Kunimi Kubo Ariga2, Thais Martins de Lima2
1Centre of Excellence in New Target Discovery (CENTD), Butantan Institute, São Paulo, São Paulo, Brazil.
まとめ
セプシスは骨髄のメゼンキマストロマ細胞 (BM- MSCs) の機能を低下させ,その分化とミトコンドリアの健康に影響します. セプシスに起因するMSCの変化は,骨髄の恒常性を乱し,患者の回復に影響を与える可能性があります.
科学分野:
- 血液学
- 細胞生物学
- 免疫学
背景:
- セプシスは通常,貧血,白血症,および血小板減少を含む血液学的異常を引き起こす.
- 骨髄メゼンキマストロマ細胞 (BM-MSCs) は血液形成と免疫調節において重要な役割を果たします.
研究 の 目的:
- BM-MSCに対するセプシスの影響を調査する.
- セプシスによるBM-MSCの変化が異常な血液形成に寄与するかどうかを判断する.
主な方法:
- BM- MSCは,シームまたはセプシス手術の8時間後にマウスから隔離されました.
- 評価されたBM-MSCの増殖,多効性,免疫フェノタイププロファイル,可塑性,ミトコンドリア機能.
- BM-MSCにおけるサイトカインとケモカインの表現を分析した.
主要な成果:
- 敗血症は骨質細胞の分化が損なわれ,可塑性の低下を示しています.
- セプシスに関連したBM-MSCは,変異した形状を持つ脱極化ミトコンドリアを示した.
- 主要なサイトカインとケモカインの発現が低下したのは,セプシスに罹患したBM- MSCにおいて観察された.
結論:
- セプシスはBM-MSCの機能的変化を誘発する.
- これらの変化は骨髄の恒常性を乱す可能性があります.
- 損傷したBM-MSCは,急性免疫反応と長期の敗血症の合併症に寄与する可能性があります.
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