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関連する概念動画

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

8.9K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.9K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

7.4K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.4K
Types of Signaling Molecules01:32

Types of Signaling Molecules

10.8K
In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
10.8K
Paracrine Signaling01:21

Paracrine Signaling

55.7K
Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
55.7K
Overview of Cell Signaling01:23

Overview of Cell Signaling

21.2K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
21.2K
Endocrine Signaling01:45

Endocrine Signaling

64.9K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
64.9K

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関連する実験動画

Updated: Sep 9, 2025

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro

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WNT信号 - メッセージを送信するために血流を使用する

Michal Caspi1, Yan Lender1, Rina Rosin-Arbesfeld2

  • 1Department of Clinical Microbiology and Immunology, Grey Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.

Cellular and molecular life sciences : CMLS
|August 29, 2025
PubMed
まとめ

Wntのシグナル伝達は発達とホメオスタシスに不可欠であり,現在,外分泌で機能することが理解されています. この経路は,血流を通る分泌された Wnt リガンドを通して循環する血液細胞に影響を与えます.

キーワード:
血液細胞流通する信号は出ない

さらに関連する動画

The Soft Agar Colony Formation Assay
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The Soft Agar Colony Formation Assay

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Studying Wnt Signaling During Patterning of Conducting Airways
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Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

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関連する実験動画

Last Updated: Sep 9, 2025

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

1.6K
The Soft Agar Colony Formation Assay
08:01

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

112.2K
Studying Wnt Signaling During Patterning of Conducting Airways
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Studying Wnt Signaling During Patterning of Conducting Airways

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科学分野:

  • 細胞生物学
  • 分子生物学
  • 生理学

背景:

  • Wnt信号伝達経路は 成長,運動,極性,分化などの 重要な細胞プロセスを制御します
  • これらの経路は胚の発達,幹細胞の再生,成人のホメオスタシスに不可欠です.
  • 伝統的にアンカーされた細胞で研究され,循環におけるWnt信号の役割は最近の調査分野です.

研究 の 目的:

  • Wntシグナル伝達のエクソクリンの機能をレビューする.
  • Wnt リガンドの源と循環動態を特定する.
  • 血液細胞における Wnt 信号構成要素の発現とその生理学的役割を調査する.

主な方法:

  • 流通中のWntシグナリングに焦点を当てた文献レビュー
  • Wnt リガンドの源と輸送を調査した研究の分析
  • 血液形成細胞におけるWnt成分発現に関する研究の検討

主要な成果:

  • Wntリガンドは,シグナリングカスケードを開始する分泌されたグリコタンパク質です.
  • 血液中でのWntカスケードが機能し,循環する細胞に影響を及ぼすという証拠があります.
  • Wntのシグナリング成分は,様々な血液細胞集団で発現する.

結論:

  • Wntシグナル伝達は 血液中の血液細胞に影響を及ぼし,外分泌特性を表します.
  • この経路は様々な種類の血液細胞において 重要な生理学的役割を果たします
  • 血液形成と免疫におけるWntの外分機能を完全に解明するには,さらなる研究が必要である.