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Updated: Sep 9, 2025

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
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編集者への手紙:PI3K/AKTシグナル伝達によるメトトレキサート誘発性腸病におけるプレボテラの役割の方法論的検討

Qin Li1, Guangzhao Zhu2

  • 1Department of Rheumatology, Qinghai Provincial Hospital of Traditional Chinese Medicine, Xining, 810000, Qinghai, China. 13260462501@163.com.

Clinical rheumatology
|August 29, 2025
PubMed
まとめ

No abstract available in PubMed .

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PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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