関連する実験動画
Updated: Sep 9, 2025
06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
23.6K
主要双方のマクロノドゥーラ性副腎増殖症 (PBMAH): 臨床実務におけるカッシング症候群の珍しい原因から一般的な原因まで
Sergii Cherenko1, Liuchiia Shchekaturova2
1Department of Endocrine Surgery, International Medical Center "CITI DOCTOR", Stepana Bandery Ave, 17/1, Kiev, 04073, Ukraine. Sergmakar5@gmail.com.
Updates in surgery
|August 29, 2025
まとめ
主要双方のマクロンモジュール性腎上腺増殖 (PBMAH) は,クッシング症候群 (CS) の原因としてますます認識されています. 腎上腺の切除は 永久的な腎上腺不全なしに 長期的寛解を可能にします
科学分野:
- 内分泌学
- 外科腫瘍学
- 腎臓の障害
背景:
- 主要な双面マクロンモジュール性腎上腺増殖 (PBMAH) は,しばしばキュッシング症候群 (CS) の珍しい原因として誤診されます.
- PBMAHの病原性,臨床表現,治療を理解することは,患者の効果的な管理に不可欠です.
- 最近のデータによると,PBMAHは以前考えられていたより頻繁に副腎CSに貢献しています.
研究 の 目的:
- PBMAH の患者の臨床的特徴と治療結果を評価する.
- PBMAH患者における共存する原発アルドステロン症の有病率を評価する.
- 腹腔鏡による腎上腺切除術の有効性と安全性を決定する.
主な方法:
- 2つの異なる期間の (2009年−2015年および2016年−2023年) 機関/病院のデータベースを遡及的に分析した.
- PBMAH症例に焦点を当てて,CSのために腎上腺切除を受けた患者を含む.
- 79人の患者の臨床状態,ホルモンレベル,治療結果の追跡評価
主要な成果:
- PBMAHは2つの研究グループでそれぞれ21%と32%の腎上腺硬化症症例を占めた.
- 患者は (平均年齢53. 4歳,女性77. 6%) 主に高血圧,肥満,高血糖,骨粗鬆症を伴う軽度のCSでした.
- 相当な割合 (44. 1% と 37. 3%) が原発アルドステロニズムと併存し,4. 7% が手術後のCS再発を経験した.
結論:
- PBMAHは 腎上腺クッシング症候群の 重要な原因であり 稀な病気ではありません
- 大腎臓の片側腹腔鏡による腎上腺切除は長期的寛解に効果があり,永久的な腎上腺不全を防ぐことができます.
- 主要なアルドステロニズムはしばしばPBMAHと関連しており,スクリーニングする必要があります.
関連する概念動画
01:27Adrenal Gland Disorders
1.8K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.8K
01:24Nephrotic Syndrome I : Introduction
27
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
27
01:31Hormones of the Adrenal Glands
2.8K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.8K
01:37Hypothalamic-Pituitary Axis
61.6K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
61.6K
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
45
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
45
01:17Anatomy of the Adrenal Glands
2.6K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
2.6K