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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

1.1K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammation01:38

Inflammation

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Overview
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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Updated: Sep 9, 2025

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
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Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Published on: December 11, 2016

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骨格筋の損傷と炎症

Tyrone A Washington1, Eleanor R Schrems2

  • 1Exercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, USA. tawashin@uark.edu.

Advances in experimental medicine and biology
|August 29, 2025
PubMed
まとめ

骨格筋の再生は 炎症反応のタイミングに依存します ニュートロフィールやマクロファージのような 免疫細胞は 破片の除去と 怪我後の筋肉の修復に 重要な役割を果たします

キーワード:
傷を負ったマクロファージ自然のキラー細胞中性粒子

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関連する実験動画

Last Updated: Sep 9, 2025

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科学分野:

  • 筋肉の生理学と再生
  • 免疫学と炎症
  • 骨格筋の損傷モデル

背景:

  • 骨格筋は驚くべき可塑性を持ち,様々な有害な刺激に反応することができます.
  • 筋肉の損傷は 組織再生に不可欠な炎症反応を引き起こします
  • 骨格の筋肉の損傷を誘発するために 標準化された方法が用いられます

研究 の 目的:

  • 骨格筋再生における炎症反応の役割を明らかにする.
  • 筋肉損傷後の免疫細胞の連続的な浸透と機能を詳細に説明する.
  • マクロファージの二極化の重要性を強調する.

主な方法:

  • 既知のモデルを用いて骨格筋損傷を誘導する.
  • 免疫細胞,特に中性粒子の浸透と活性化を監視する.
  • 炎症性 (M1) から抗炎症性 (M2) のフェノタイプへのマクロファージの移行を観察する.

主要な成果:

  • 中性粒子は最初の反応体で 破片を取り除き マクロファージを集めます
  • マクロファージはM1フェノタイプからM2フェノタイプに変化します.
  • M2マクロファージは,筋肉の修復に必要な筋細胞反応の開始に不可欠です.

結論:

  • 炎症反応は骨格筋の最適回復のために不可欠です.
  • 炎症カスケードの障害,特にマクロファージの偏化は,筋肉の再生を妨げます.
  • このプロセスを理解することは 筋肉の損傷に対する 治療戦略を策定する上で 鍵となるものです