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Neuroplasticity01:01

Neuroplasticity

752
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
752
Epigenetic Regulation01:37

Epigenetic Regulation

3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

1.9K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
1.9K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Forced Transdifferentiation01:28

Forced Transdifferentiation

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Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
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Overview of Muscle Tissues01:25

Overview of Muscle Tissues

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The human body has three types of muscle tissue: skeletal, smooth, and cardiac. Each class has unique properties that enable them to perform specific functions. However, all muscle tissues share certain properties, including elasticity, contractility, and excitability. 
Elasticity
Elasticity is the ability of muscles to stretch and return to their original shape. This property is partly due to elastic fibers — macromolecules that run through the muscles. These fibers are firm and...
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関連する実験動画

Updated: Sep 9, 2025

Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle
09:30

Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle

Published on: November 6, 2017

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筋肉の可塑性,適応性,表遺伝学

Jonathan Charles Jarvis1

  • 1School of Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK. J.C.Jarvis@ljmu.ac.uk.

Advances in experimental medicine and biology
|August 29, 2025
PubMed
まとめ
この要約は機械生成です。

骨格の筋肉は 運動の要求に適合し 耐久性やスプリントの特徴を 発達させる. この驚くべき細胞の可塑性は 運動能力や老化 代謝の健康に不可欠です

キーワード:
運動反応筋肉の適応筋肉繊維の種類筋肉トレーニングプラスチック性

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Isolation and Differentiation of Primary Myoblasts from Mouse Skeletal Muscle Explants
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Isolation and Differentiation of Primary Myoblasts from Mouse Skeletal Muscle Explants

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Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue
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Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue

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関連する実験動画

Last Updated: Sep 9, 2025

Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle
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Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle

Published on: November 6, 2017

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Isolation and Differentiation of Primary Myoblasts from Mouse Skeletal Muscle Explants
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Isolation and Differentiation of Primary Myoblasts from Mouse Skeletal Muscle Explants

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Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue
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Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue

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科学分野:

  • 筋肉の生理学
  • 細胞の適応
  • 神経筋肉科学

背景:

  • 骨格筋は成人細胞において有意な表型可塑性を表している.
  • 筋肉繊維は活動パターンの変化に適応し,遺伝子発現とタンパク質プロフィールに影響を与えます.
  • この適応はホルモン信号と 機械的な刺激によって影響を受けます

研究 の 目的:

  • 筋肉の表型適応の歴史的証拠と実験モデルをレビューする.
  • 変化した活動に対する 筋肉の反応の基礎となる 分子機構を強調する.
  • 筋肉の適応の生理学的重要性を強調する

主な方法:

  • 筋肉の適応に関する過去の実験データのレビュー
  • トランスクリプトミック,エピジェノミック,プロテオミック分析からの発見の統合.
  • 神経筋の生理学の研究のための実験モデルにおける進歩に焦点を当てます.

主要な成果:

  • 大人の筋肉細胞の微分化において,有意な表型適応の実証.
  • 活動パターンに基づく"耐久性"と"スプリント"現象の特定
  • 筋肉の適応を促す多面的な細胞内メカニズムの解明

結論:

  • 筋肉の表型適応は神経筋肉の生理学の基本的側面である.
  • これらの適応を理解することは 運動訓練や 歳を取ることで起こる 筋肉の喪失や 代謝の健康に不可欠です
  • 実験モデルの進歩により 細胞の可塑性について より深い洞察が得られます