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Updated: Jul 4, 2026

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Sara Rodrigues1,2, Cláudia Gonçalves3, Oksana Golovko4

  • 1Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre S/N, Porto, 4169-007, Portugal. sara.rodrigues@fc.up.pt.

Ecotoxicology (London, England)
|August 29, 2025
PubMed
まとめ

No abstract available in PubMed .

キーワード:
行動生化学的なエンドポイント新しく発生する汚染物質大型水精神刺激剤生殖パラメータ

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...