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Updated: Sep 9, 2025

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
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Konjac Oligosaccharideは,5-HT4R/cAMP/PKA/p-CREB経路の活性化によってマウスの便秘を緩和する

Guang-Jun Sun1,2,3, Ming Li4, Xiao-Yu Zhang1,2,3

  • 1Department of Proctology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, China.

Current medical science
|August 29, 2025
PubMed
まとめ

コニャック・オリゴサッカライド (KOS) は,5-HT4R/cAMP/PKA/p-CREB経路を活性化することで,便秘を和らげる. このメカニズムは 滑らかな筋肉細胞の増殖を促し 便秘に対する新しい治療法を提供します

キーワード:
5-HT4受容体についてCAMP/PKAシグナリング大腸の運動機能性便秘腸の運動性コニャックオリゴサクライド (KOS)ロペラミド滑らかな筋肉細胞

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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