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Updated: Jun 14, 2026

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統合的ゲノム分析は,肝臓転移の結腸直腸がん患者の臨床的に重要な予後マーカーを特定します

Wentao Li1, Ming Liu2, Liula Wu1

  • 1Department of Gastroenteroanal Surgery, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|August 29, 2025
PubMed
まとめ

大腸直腸転移 (CRLM) のゲノム分析により,主要な変異と経路が特定されました. これらの要因を統合することで,全生存率 (OS) の予測が改善され,患者のリスクの階層化が改善されます.

キーワード:
結腸直腸転移ゲノムの風景ノモグラム全体の生存率予測要因

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...