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Updated: Sep 9, 2025

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ATG結合依存/独立メカニズムは,リソソーム性ストレス誘発TFEBの制御の基礎となっている

Shiori Akayama1,2, Takayuki Shima2,3, Tatsuya Kaminishi4

  • 1Graduate School of Frontier Biosciences, Osaka University , Suita, Japan.

The Journal of cell biology
|August 29, 2025
PubMed
まとめ

この研究は,細胞のストレス中にTFEB (転写因子EB) 調節の2つの新しいモードを明らかにしています. モードIはTFEBの安定性を確保するためにAPEX1を使用し,モードIIはACT7/TRIP6を使用してアクティベーションをブロックし,TFEBの制御を統一的に表示します.

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