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Updated: Sep 9, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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In Vitro Analysis of E3 Ubiquitin Ligase Function

Published on: May 14, 2021

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UBR1およびUBR2ユビキチンE3リガゼによるN-デグロンの結合のための代替ポケット

Shih-Ting Huang1, Dai-Hua Chen2, Tianchen Ren1

  • 1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.

Protein science : a publication of the Protein Society
|August 29, 2025
PubMed
まとめ

研究者らは,UBR1とUBR2ユビキチンリガゼのUBRボックスの新しい結合ポケットを発見した. このポケットはN-デグロンの第2の残留物と相互作用し,E3リガースの調節と治療開発に関する新しい洞察を明らかにします.

キーワード:
N-end ルールUBR1 についてUBR2 についてクリスタル構造光極化ユビキチン

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