29人の糖尿病の猫における非ケト性高血糖症に関連した予測変数と全生存率の遡及的評価 (2000-2020年)
Annalisa Judy1, Aaron Rendahl1, Kelly Tart1
1University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota, USA.
まとめ
ハイポスモラ高血糖状態 (HHS) と糖尿病性ケトアシドーシス (DKA) の猫の生存率は類似した. アゾテミア,低血糖症,高血糖症,低体温などの臨床症状は,糖尿病の危機的な猫ではより悪い結果を示した.
科学分野:
- 獣医学
- 内分泌学
- 内科 医学
背景:
- 糖尿病性ケトアシドーシス (DKA) とハイポスモラー高血糖状態 (HHS) は,猫における重度の糖尿病合併症である.
- DKAとHHSを区別することは,予後と治療戦略にとって極めて重要です.
研究 の 目的:
- 猫のDKAとHHSの生存率を比較する
- ハイパーグリセミックな糖尿病の危機を持つ猫の生存に関連する臨床的および臨床病理学的要因を特定する.
主な方法:
- 2000年から2020年にかけての大学院病院の医療記録の遡及分析.
- 含有基準は,DKAとHHSの特定の血糖値,オスモラリティ,ケトン値を定義した.
- 生存データと様々な臨床パラメータを収集し,分析した.
主要な成果:
- HHS (65. 5%) とDKA (68. 6%) の全生存率は有意に異なるものではありませんでした.
- 特定の臨床病理学的パラメータやインスリンタイプは,HHS群での生存を予測しなかった.
- すべての猫では,高いBUN,クレアチニン,および血糖,低ナトリウムと体温は,生存率の低下と相関しています.
結論:
- 猫のHHS生存率はDKAと同等であり,これらの症候群の重複の可能性を示唆している.
- HHSの予後指標は特定されなかったが,疾患の重度の一般的なマーカーは両群の生存に影響を及ぼした.
- アゾテミア,低ナトリウム血量,高血糖,低体温は,ネコの高血糖危機における陰性予後指標である.
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