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Updated: Sep 9, 2025

Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling
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IRES依存の翻訳とATF4駆動の代謝適応を維持するために,rRNA標的 hnRNP A1のDKC1媒介型偽ウリジル化

Anamika Gupta1,2, Mohit Bansal1,2, Jane Ding1,2

  • 1Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Science advances
|August 29, 2025
PubMed
まとめ

癌において上調される偽ウリジン合成酵素DKC1は,hNRP A1媒介体を通してATF4発現と代謝適応を促進することによって,癌細胞の生存を維持する. これは癌の進行における 重要な経路を示しています

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