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Updated: Sep 9, 2025

Flow Cytometric Characterization of Murine B Cell Development
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IgMとIgG1のB細胞受容体は,B細胞の運命を差異的に影響し,成熟したB細胞リンパ腫の病原性を決定する

Rebecca M Southern1, Rebecca L Schmitz1, Daniela Samaniego-Castruita1

  • 1Department of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA.

Science advances
|August 29, 2025
PubMed
まとめ

拡散型大B細胞リンパ腫 (DLBCL) のアウトカムは,高い免疫グロブリンM (IgM) B細胞受容体 (BCR) 発現で悪化する. IgG1 BCRはミトコンドリア機能障害と生存率の低下を引き起こし,B細胞リンパ腫の病原性に影響する.

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