韓国の妊婦におけるAST/ALT比と妊娠糖尿病のリスクとの関連
Dongqian Yang1, Yuqin Shen2, Rong Shuai1
1Department of Laboratory Medicine, Changde Hospital, Xiangya School of Medicine, Central South University (The first people's hospital of Changde city), Changde, Hunan, China.
PloS one
|August 29, 2025
まとめ
妊娠初期におけるアスパルテートアミノトランスフェラーゼとアラニンアミノトランスフェラーゼ (AST/ ALT) の比率は,妊娠中の糖尿病 (GDM) のリスクの低下と関連しています. この発見は,AST/ALT比が初期のGDMバイオマーカーである可能性を示唆しています.
科学分野:
- 内分泌学
- 代謝 健康
- 生殖医学
背景:
- アスパルテートアミノトランスフェラーゼとアラニンアミノトランスフェラーゼ (AST/ ALT) の比率は,インスリン抵抗性および糖尿病と関連していることが知られている.
- しかし,妊娠中糖尿病 (GDM) の特定の役割は,未熟のままである.
研究 の 目的:
- 妊娠中の韓国女性の集団におけるAST/ALT比とGDMの関連性を調査する.
- AST/ALT比がGDMリスクの早期予測要因として機能するかどうかを判断する.
主な方法:
- 575人の独身妊娠 (10~14週) の女性を対象とした前向きなコホート研究の二次分析.
- AST/ALT比は連続変数と四分の1のカテゴリ変数として分析される.
- 関連性を評価するために,ロジスティック回帰,サブグループ,感度分析,および制限立方スライン (RCS) のフィッティングを使用した.
主要な成果:
- 平均AST/ ALT比は1. 6±1. 0でした.
- 混同因子を調整した結果,AST/ ALT比の低下はGDMと有意かつ否定的に関連していた (OR=0. 45,95%CI: 0. 2- 0. 99).
- 敏感性およびサブグループ分析は,この関連性の強さを確認した.
結論:
- 妊娠初期におけるAST/ALT比の低下は,独立してGDMの発症リスクと否定的に関連しています.
- AST/ALT比は,GDMのリスクが高い妊婦を早期に特定するためのバイオマーカーとして潜在的であることを示しています.
- このバイオマーカーは,GDMの標的型予防戦略の開発に役立ちます.
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