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SelectMDx尿路バイオマーカーの評価による前立腺画像報告の管理の精製

Petrino-Cristian Calinoiu^1,2, Daniel Badescu^1,2, Ovidiu-Catalin Nechita^1,2

¹Department of Urology, "Prof. Dr. Th. Burghele" Clinical Hospital, Bucharest, Romania.

|August 29, 2025

まとめ

SelectMDxの尿検査は,PI- RADS3の病変を有する男性における前立腺がんのリスクの分化に役立ちます. 臨床的に有意な前立腺がんを特定し,不必要な生検を減らすことができます.

科学分野:

泌尿器科
腫瘍学
バイオマーカーの研究

背景:

PI- RADS 3の病変を有する男性における多パラメータ磁気共鳴画像 (mpMRI) の前立腺がんの診断は困難です.
不必要な前立腺生検を避けるにはリスクの正確な分層化が不可欠です

研究の目的:

SelectMDx尿路バイオマーカーテストの臨床的有用性を評価する.
臨床的に有意な前立腺がんのリスクの階層化を改善するかどうかを評価する.
SelectMDxが不必要な前立腺生検の割合を減らすことができるかどうかを判断する.

主な方法:

PSA ≥3ng/ mlとPI- RADS ≥3の病変を有する40人の患者による前向きなコホート研究.
DLX1とHOXC6のmRNA発現を測定するSelectMDxテストを用いた尿サンプル分析
SelectMDxの結果と生検で確認された前立腺がんの診断の比較

主要な成果:

SelectMDxは,バイオプシーで確認された臨床的に有意な前立腺がんと有意な相関を示した (57. 1% 陽性対 18. 2% 陰性,p=0. 031).
検査は57. 14%の感度,81. 82%の特異性,90%の負の予測値を示した.
SelectMDxは悪性腫瘍を除外し,選択的な生検戦略を導く可能性を示した.

結論:

SelectMDx検査は,PI-RADS3の病変を有する男性におけるリスクの分層化に役立つツールです.
バイオプシーの恩恵を受ける患者やバイオプシーの恩恵を受けない患者を特定するのに役立ちます.
前立腺がんの診断のための臨床的意思決定への統合を後押しする研究も行われます.

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