刺激性腸症候群患者の低FODMAPダイエット後の循環GLP-1の増加
Umael Khan1, Ingeborg Brønstad1,2, Eline Margrete Randulff Hillestad3,4
1Section of Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Frontiers in nutrition
|August 29, 2025
まとめ
FODMAPの少ない食事により,IBSの症状が著しく改善され,刺激性腸症候群 (IBS) の患者でグルカゴン型ペプチド-1 (GLP-1) レベルが上昇しました. 腸内ホルモンの調節に影響を与えることでIBSの管理の可能性を示しています
科学分野:
- 胃腸内科
- 内分泌学
- 人間 の 栄養
背景:
- 発酵可能なオリゴサッカライド,ディサッカライド,モノサッカライド,ポリオール (FODMAPs) とグルカゴン様ペプチド-1 (GLP-1) は,イリタブル・ボウル・シンドローム (IBS) の病理生理学と独立して関連している.
- IBS患者の循環GLP-1レベルに対するFODMAPの少ない食事の影響に関する研究は限られている.
研究 の 目的:
- IBSと診断された患者の血GLP-1レベルに対する12週間の低FODMAPダイエットの効果を調査する.
- 食事療法によるIBS症状の重度と体重の変化を評価する.
主な方法:
- 30人のIBS患者 (下痢または混合型) が12週間の低FODMAPダイエットに参加しました.
- 血のGLP-1濃度,IBS重度スコアシステム (IBS- SSS),体重,介入前および介入後のFODMAP摂取量を測定した.
主要な成果:
- FODMAPの少ないダイエットは,IBS-SSSの平均値と体重の有意な減少をもたらしました (p < 0. 01).
- プラズマGLP-1濃度は12週間の食事介入後に有意に上昇した (p=0. 027)
結論:
- 12週間の低FODMAPダイエットは,IBS患者の血GLP-1レベルを上昇させる可能性があります.
- このGLP-1の増加を促す具体的なメカニズムは,さらなる調査が必要である.
関連する概念動画
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
413
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
413
Drugs for Treatment of Constipation-Predominant IBS
326
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
326
Irritable Bowel Syndrome III: Medical and Nursing Management
294
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
294
Drugs for Treatment of Diarrhea-Predominant IBS
292
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
292
Irritable Bowel Syndrome I: Introduction
369
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
369
Glucagon-like Receptor Agonists
416
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
416


