腸内微生物群と歯周病の食事指数との関連:全身性炎症による媒介
J H Zhu1, Gehong Sun2, Jia Guo2
1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Frontiers in nutrition
|August 29, 2025
まとめ
ダイエット・インデックス・フォー・ガート・マイクロバイオタ (DI-GM) に従うことは,歯周病のリスクの低下と関連しています. 歯周病の予防における食事の役割を示唆する.
科学分野:
- 微生物群の研究
- 歯周病学
- 栄養学
背景:
- 歯周病は 歯茎と支える構造に影響を与える 流行する炎症性疾患です.
- 腸内微生物の組成は食事によって影響を受け,全身の健康に影響を及ぼします.
- 歯周病を含む様々な慢性疾患には全身性炎症が関与している.
研究 の 目的:
- 腸内微生物の食事指数 (DI-GM) と歯周病との関連を調べる.
- DI-GMと歯周炎の関係における全身性炎症の潜在的な媒介的役割を調査する.
主な方法:
- 2009年から2014年にかけて実施された国家健康栄養調査 (NHANES) に参加した9022人の横断分析.
- DI-GMスコアは14の食事成分から計算され,歯周病はCDC/AAPの基準を用いて定義された.
- 多変数ロジスティック回帰,制限立方筋,およびメディエーション分析が行われました.
主要な成果:
- DI- GMのスコアが高くなった場合,歯周病の罹患率と逆相関を示した (ORは1ポイント増加で0. 95,p < 0. 001).
- 最も高いDI-GM群の個人は,中度 (19%) と重度の (26%) 歯周病の確率が有意に低かった.
- 系統的炎症バイオマーカー,特にCRP (8. 1%) とWBC (5. 5%) は,部分的に関連性を介した.
結論:
- DI-GMのより高い遵守は,歯周炎のより低い流行と関連しています.
- 系統的炎症は,この関連において部分的に仲介的な役割を果たします.
- 腸内微生物群の食事調節は歯周病の予防のための潜在的な戦略です.
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