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Updated: May 5, 2026

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells
10:13

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells

Published on: July 3, 2013

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NRF2誘発がんを抑制するアロステリック14-3-3阻害剤の発見

Jinglong Zhao1, Han Jiang1, Kaimei Zhao1

  • 1Jiang Su Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University Nanjing 210009 China youqd@163.com jiangzhengyucpu@163.com.

Chemical science
|August 29, 2025
PubMed
まとめ

研究者らは,がんにおける過活性のNRF2経路を標的とする14-3-3の新型アロステリック阻害剤WS3を特定した. この発見はNRF2が誘発する腫瘍と 癌の治療に対する耐性を 治療するための新しい戦略を提供します

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Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

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A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction05:28

A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction

Published on: August 27, 2019

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