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Updated: Sep 9, 2025

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy
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Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy

Published on: September 12, 2019

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βシート折り畳みと繊維分解におけるアミジンの"イン"と"アウト"

Emily A O'Brien1, Mohaddeseh Abbasi1, Jeffrey A Purslow1

  • 1Department of Chemistry, Iowa State University Ames IA 50011 USA bvv@iastate.edu.

Chemical science
|August 29, 2025
PubMed
まとめ

ベータシート構造のアミジンイソステルはドナーとしてよく耐えるが,受容体として折り畳みを破壊する. この非対称性は,結合しないペプチドミメティックを設計し,バイオ分子におけるアミジン塩基性を明らかにします.

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