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Updated: Sep 9, 2025

Identification of Kinase-substrate Pairs Using High Throughput Screening
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キナーゼシグナリングカスケード: 更新されたメカニズムの風景

Ruth Nussinov1,2,3, Clil Regev3, Hyunbum Jang1,3

  • 1Computational Structural Biology Section, Frederick National Laboratory for Cancer Research MD 21702 USA NussinoR@mail.nih.gov.

Chemical science
|August 29, 2025
PubMed
まとめ

この研究は,MAPKやPI3K/AKT/mTORのようなキナーゼカスケードを通じた細胞増殖シグナル伝達の物理化学的基礎を明らかにし,細胞寿命とがん薬の標的化のための速度と精度がどのように達成されるかを明らかにしています.

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