成人の腸-脳相互作用の障害の危険因子である早産:症例対照研究
Olivier Courbette1, Camille Girard-Bock2, Anik Cloutier2
1Department of Pediatric Gastroenterology, Sainte-Justine University Hospital Center, Montreal H3T1C5, Quebec, Canada. olivier.courbette@gmail.com.
World journal of clinical pediatrics
|August 29, 2025
まとめ
腸機能障害を含む腸-脳相互作用障害 (DGBI) を発症するリスクが高くなります. このリスクは,早産,精神的健康,性に関係する要因に左右されます.
科学分野:
- 胃腸内科
- 新生児科
- 精神科
背景:
- 腸-脳相互作用障害 (DGBI) は慢性的な胃腸症状を伴う.
- 早期のストレス要因は,DGBIの潜在的要因です.
- 胎児の早産と新生児の要因は,DGBIの発達に影響を与える可能性があります.
研究 の 目的:
- 妊娠早産と成人期におけるDGBIの発症との関連を調査する.
- 胎児におけるDGBIに影響を与える特定の新生児要因を特定する.
主な方法:
- 超早産 (妊娠29週未満) と対照群を対象とした症例対照研究.
- DGBIの評価のためにローマIV診断アンケートを使用した.
- 新生児の要因,社会人口統計,不安,うつ病に関するデータを収集した.
主要な成果:
- 早期出産した成人は,機能的腸疾患の有意に高い罹患率を示した.
- 早期出産の女性では 機能性胃腸関節障害,機能性腸関節障害,機能性便秘の割合が増加しました.
- 危険因子には,早産に関連した状態,心理的要因 (不安,うつ),女性の性別が含まれています.
結論:
- 胎児の早産は,DGBIの発症の重要な危険因子として確認されています.
- この研究は,早産の成人の集団をよく特徴づける最初のケース・コントロールの証拠を提供します.
- 発見は早産が腸と脳との相互作用に 長期的な影響を及ぼすことを示しています
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