ロペラミド水塩化物による便秘に対するマレン・ジジュ乳液の緩和効果と腸内微生物群への影響

Xinran Han¹, Yuankun Chai¹, Na Li^1,2

¹College of Pharmacy, Changchun University of Chinese Medicine, Changchun, China.

Frontiers in microbiology

|August 29, 2025

まとめ

マレン・ジズー乳液 (MRZZ) は,伝統的な中国薬で,ネズミの便秘を効果的に緩和しました. 腸内微生物群を改善し有益な短鎖脂肪酸を増やし炎症を軽減し治療の可能性を強調しました

科学分野:

胃腸内科
薬理学について
微生物学

背景:

便秘は世界的な健康問題です
伝統的な中国医学 (TCM) は,便秘の補助療法としてますます使用されています.
Maren-Zhizhuエムルション (MRZZ) は,潜在的な利点を持つTCM製剤である.

研究の目的:

マウスにおけるロペラミド水塩化物による便秘の緩和におけるMRZZの有効性を評価する.
腸内微生物群と胃腸機能への影響を含め,MRZZの作用の根本的なメカニズムを調査する.

主な方法:

MRZZはマウスに14日間,低用量および高用量で経口投与された.
便秘はロペラミド塩化物によって誘発された.
分析には結腸組織病理学,トランスクリプトミクス,腸内微生物の構成,糞便の水分含有量,胃腸経路,短鎖脂肪酸 (SCFA) 濃度,血清の胃腸調節性ペプチド濃度が含まれていた.

主要な成果:

MRZZは糞便の水分量を改善し,胃腸経路を加速し,最初の黒い便までの時間を短縮しました.
神経伝達物質 (MTL,SP,GAS) とSCFA (アセテート,イソブチレート) を増加させた.
MRZZはFirmicutesを増加させ,Proteobacteriaを減少させ,腸の炎症を抑制し,腸の機能を向上させ,腸内微生物群を調節した.

結論:

MRZZはマウスモデルでの便秘の緩和に有意な効果を示しています.
治療効果は腸内微生物群,神経伝達物質のレベル,および抗炎症作用の相乗的調節に起因する.
MRZZは TCMベースの便秘治療として有望です

キーワード:

便秘エムルション腸内微生物群中国伝統医学トランスクリプトミクス

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