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Updated: Sep 9, 2025

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
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ヒスタミンH1受容体の光スイッチ可能なデスロラタジンリガンドの設計と合成

Lars C P Binkhorst1, Ivana Josimovic1, Daan de Vetten1

  • 1Amsterdam Institute of Molecular and Life Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam De Boelelaan 1083 1081 HV Amsterdam The Netherlands m.wijtmans@vu.nl r.leurs@vu.nl.

RSC medicinal chemistry
|August 29, 2025
PubMed
まとめ

研究者らは,デスロラタジンを改変することによって,ヒスタミンH1受容体 (H1R) に対する新しい光スイッチリガンドを開発した. この重要なGタンパク質結合受容体 (GPCR) の光学制御のための有望な化合物を同定した.

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