関連する実験動画

Updated: Sep 9, 2025

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells
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Published on: June 16, 2022

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腫瘍性RNA結合タンパク質 HuR の薬剤のような分子分解剤

Liann Kassabri1, Raphael I Benhamou1

  • 1The Institute for Drug Research of the School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91121, Israel.

JACS Au
|August 29, 2025
PubMed
まとめ

Hu抗原R (HuR) タンパク質を標的とした小分子は,分子接着剤とPROTACを用いて,がん細胞の成長を効果的に抑制しました. この標的型タンパク質分解戦略は 侵襲的な乳がんやその他のRNA駆動性疾患の 治療に有望であることが示されています

キーワード:
3DがんモデルHUR についてプロタックRNA 結合タンパク質二機能分子二相分解乳がん劣化剤分子接着剤治療的な

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