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Updated: Sep 9, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

10.1K

DNAプログラム可能なタンパク質分解:DNAハイブリッド化とストランド移位によるタンパク質分解標的キメラ活動のダイナミック制御

Disha Kashyap1,2, Shozeb Haider3,4,5, Thomas A Milne2

  • 1Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.

JACS Au
|August 29, 2025
PubMed
まとめ

DNAナノテクノロジーは,タンパク質分解を標的とするキメラ (PROTAC) の正確な制御を可能にします. オリゴヌクレオチド結合PROTAC (オリゴプロタC) は,距離依存の分解とダイナミックなオフスイッチを提供し,治療の安全性と機能を強化します.

キーワード:
BRD4の分解DNAナノテクノロジーJQ1 についてプロタックVH032 についてVHL E3リガゼオリゴヌクレオチド関連PROTACトホールド媒介の糸の移転

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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes07:22

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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Regulated Protein Degradation02:58

Regulated Protein Degradation

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The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
The proteasome is an...
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