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Updated: May 6, 2026

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
07:50

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina

Published on: August 29, 2018

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マルチオミクスのデータを統合すると,網膜の色素表皮における不規則なRNAメチル化が,年齢関連のマキュラ変性を引き起こすことが明らかになる

Ya-Jun Gong1, Zhi-Lin Zou1, Kai-Rui Qiu1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University; Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science; Guangdong Basic Research Center of Excellence for Major Blinding Eye Diseases Prevention and Treatment, Guangzhou 510060, Guangdong Province, China.

International journal of ophthalmology
|August 29, 2025
PubMed
まとめ

RNAメチル化は,年齢関連の黄斑変性 (AMD) の網膜細胞で調節不能である. METTL3やNSUN6のような重要な遺伝子は保護効果を示し,MRM1はAMDのリスクを高め,潜在的な治療標的を提供している.

キーワード:
RNA メチル化年齢による黄斑変性網膜のピグメント上皮

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Author Spotlight: Extended Oxygen Consumption Measurement in Retinal Pigment Epithelium Using Resipher08:09

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Nucleotide Excision Repair

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Changes in Skin Color: Clinical Perspectives

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Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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