2つの症例の報告と文献のレビュー
Hironobu Komine1,2, Takao Nagashima1, Hiroki Yabe1
1Division of Rheumatology, Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama, JPN.
Cureus
|August 29, 2025
まとめ
抗メラノーマ分化関連遺伝子5 (MDA5) 抗体に関連した再発性皮膚炎 (DM) は,長い寛解期を経て発生することがあります. これは,DM患者の抗MDA5抗体の再出現をモニタリングすることの重要性を強調しています.
科学分野:
- リウマトロジ
- 免疫学
- 皮膚科
背景:
- 抗メラノーマ分化関連遺伝子5 (MDA5) 抗体陽性皮膚炎 (DM) は自己免疫疾患である.
- 長期的寛解は,サイクロフォスファミドを含む免疫抑制療法で達成可能である.
- 抗体陰性化が達成された後でも,疾患の再発の可能性については,さらなる調査が必要である.
関連する概念動画
01:20Myasthenia Gravis: Overview and Treatment
1.9K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.9K
01:30Skin Cancer
4.5K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.5K