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Updated: Sep 9, 2025

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level
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人間の血管アトラスの単細胞トランスクリプトミックの分析は,血管緩解の冗長性と異質性に関する新しい洞察を提供します

Elisa Avolio1, Sarah F Pearce1, David Wambeke2

  • 1Experimental Cardiovascular Medicine, University of Bristol, Bristol, United Kingdom.

Frontiers in cardiovascular medicine
|August 29, 2025
PubMed
まとめ

人間の血管細胞は,細胞タイプと年齢によって異なる血管リラックス剤遺伝子の多様な発現を示します. この異質性は窒素酸化物とプロスタサイクリン経路に影響を与え,血管トーンを複雑に調節することを示唆しています.

キーワード:
ブラジキニン受容体 (b1R/b2R)内皮酸化窒素合成酵素 (eNOS)グアノシントリホスファート (GTP)プロスタグランジンH合成酵素 (PGHS)プロスタグランジンH2 (PGH2)タンパク質キナーゼg (PKG)溶性ガニラートサイクラゼ (sGC)

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